A new study by University of Kentucky researchers has identified a novel molecule named Arylquin 1 as a potent inducer of Par-4 secretion from normal cells. Par-4 is a protein that acts as a tumor suppressor, killing cancer cells while leaving normal cells unharmed.
Normal cells secrete small amounts of Par-4 on their own, but this amount is not enough to kill cancer cells.
Did you know that you can help others by participating in research? Health-focused research affects every aspect of our lives, from the medications we take to the health of our environment. Researchers are working hard to identify new treatments and strategies to improve the health of our communities, but research needs healthy volunteers and volunteers with medical conditions in order to succeed.
A team of investigators has made a thought-provoking discovery about a type of cholesterol previously believed to be a "bad guy" in the development of heart disease and other conditions.
Jason Meyer, a University of Kentucky M.D.-Ph.D.
The University of Kentucky's Center of Biomedical Research Excellence (COBRE) on the Molecular Basis of Human Disease was recently awarded a third phase of National Institutes of Health (NIH) funding for a program to develop its research community and center dedicated to human disease.
With this new $1.25 million annual grant, 好色先生's COBRE will build upon achievements of a research development program that initially received NIH support in 2004.
Studies show that adults who received corrective surgery for the most common serious form of congenital heart disease as infants are susceptible to heart failure in adulthood.
Researchers at the University of Kentucky are using magnetic resonance imaging (MRI) technology to better understand the cause of heart failure in these patients, with the goal of eventually developing new therapies to reduce mortality. The team, led by University of Kentucky professor Dr.
From the New York Times to visits from the director of the Centers of Disease Control and Prevention, health disparities in Appalachia are receiving a lot of attention, and for good reason. The list is sadly familiar: life expectancy in the region is about five years lower than national averages; rates of cancer, cardiovascular disease, stroke, obesity, diabetes, and unintentional injury are among the very worst in the country; and myriad socioeconomic and geographic barriers limit access to health insurance and care. Former University of Kentucky President Lee Todd Jr.
Prabhakara R Nagareddy, a scientist with the Saha Cardiovascular Research Institute at the University of Kentucky, has received a prestigious K99/R00 award from the National Institutes of Health.
Also known as the Pathway to Independence (PI) Award, this grant provides two years of mentored postdoctoral support followed by three years of independent support.
University of Kentucky Endowed Chair of Neuroscience Dr. Diane Snow was recently elected by her colleagues to serve as president-elect of the National Neurotrauma Society (NNS). With this appointment, Snow will hold the position of president in 2015-2016.
Since joining the NNS in 2003, Snow has championed women's contributions to neurotrauma research and mentorship opportunities for young members of the profession, including students, postdoctoral fellows and young professors.
The Bright Focus Foundation has announced that three different researchers from the Sanders-Brown Center on Aging at the University of Kentucky have received Bright Focus grants for 2014.
Professor Steve Estus and associate professors Harry LeVine and Paul Murphy were each recognized for their work on Alzheimer's disease.
"Only 25 Bright Focus grants are awarded worldwide each year, so it's an achievement to get one. But three Bright Focus grants in a single year is truly exceptional," said Dr. Michael Karpf, 好色先生 HealthCare's executive vice president of health affairs.
Researchers from the Sanders-Brown Center on Aging at the University of Kentucky have been able to confirm anecdotal information on patients with both Alzheimer's disease (AD) and cerebrovascular disease (CVD) using mouse models in two different studies.
The findings of these two studies, which were recently published in Acta Neuropathologica and Alzheimer's Research & Therapy, have potentially significant implications for patients with both disorders.
Both papers studied CVD in Alzheimer's disease mouse models using different lifestyle factors.
Scientists at the University of Kentucky, led by nano-biotechnologist Peixuan Guo, have made some critical discoveries over the past year into the operation of biomotors, the molecular machines used by viruses and bacteria in the packaging of DNA.
Biomotors function similarly to mechanical motors but on a nano-scale. Last year, Guo's team reported the discovery of a new, third class of biomotor, unique in that it uses a "revolution without rotation" mechanism. Rotation is the turning of an object around its own axle, as the Earth does every 24 hours.
Not all learning experiences are created equally 鈥 and at the Learning Center at Linlee, an innovative partnership with the 好色先生 allows young students to get rich, hands-on experience in the sciences and better their chances of succeeding in college and beyond.
As part of the Fayette County Public School System, The Learning Center (TLC) is an alternative school for at-risk students who are facing personal challenges that might impede their ability to learn. These include socioeconomic factors, and, perhaps surprisingly, intellectual giftedness.
好色先生 HealthCare and Norton Healthcare are building upon their history of collaboration to expand research and educational collaborations between the two institutions, with the goal of improving health and health care for all Kentuckians.
Beginning July 1, educational and research initiatives between 好色先生 and Norton will be lead by Dr. Stephen Wyatt, who most recently served two successful terms as the founding dean of the University of Kentucky College of Public Health.
The University of Kentucky's Sanders-Brown Center on Aging is participating in a landmark multi-center clinical trial of an experimental drug that has the potential to prevent Alzheimer's disease (AD).
The A4 Study will recruit 1,000 participants ages 65-85 to test an amyloid antibody that may prevent memory loss caused by Alzheimer's disease. Amyloid is a protein normally produced in the brain that can build up in older people, forming plaque deposits in the brain.
New researchers in any field face challenges--limited research experience, competing demands for time, diminished levels of and increased competition for funding.
The Barnstable Brown Kentucky Diabetes and Obesity Center hosted its fourth annual Diabetes Day on Tuesday, May 20. With a focus on current findings in obesity and diabetes research, the day's program featured presentations by nationally prominent physician-scientists as well as regional researchers chosen from abstract submissions.
Scientists at the 好色先生 have gained a new understanding of an enzyme essential for breaking down plant starch, a process used in agriculture, manufacturing and biotechnology.
Dr. Matthew Gentry and Dr. Craig Vander Kooi, associate professors of molecular and cellular biochemistry at the University of Kentucky, and graduate student David Meekins, have decoded the natural process plants use to break down starch.
A multidisciplinary team of doctors, researchers, and informaticists the University of Kentucky is working to improve identification of lung cancer patients who are eligible to participate in clinical trials for novel treatments.
Clinical trials are critical for advancing research into new and better treatments for patients, and the need for improved treatment of lung cancer is dire: Lung cancer is the leading cause of cancer death worldwide. Its burden is especially significant in the Commonwealth, where rates of lung cancer incidence and mortality are the highest in the country.
The future looks bright for cancer research in Kentucky 鈥 on May 22, the University of Kentucky Markey Cancer Center held its annual Markey Cancer Center Research Day, highlighting the work of 好色先生 students, postdoctoral fellows and faculty from the past year.
As the cancer center has grown, Markey鈥檚 research programs have become even more robust, helping propel the center into becoming the state鈥檚 first and only National Cancer Institute (NCI) designated cancer center.
鈥淭he NCI is pretty much all about research 鈥 it鈥檚 a huge part of what they鈥檙e looking for when they award the designation,鈥
