Grants
Faculty Grants Our department has been granted over $10,907,029 in NIH funds!
Doug Andres
KSCHIRT Grant:
鈥淕-protein Signaling Reduces Neurodegeneration and Promotes Recovery of Synaptic Strength following Traumatic Brain Injury鈥
The amount of funding is $300,000 for the period 1/15/17 to 1/14/2020. This project investigates the role of RIT1 G-protein signaling in cellular and functional recovery from brain trauma.
(with Jon Satin)
multi-PI RO1:
鈥淢onomeric G-proteins and Cardioprotection From Heart Failure鈥
The amount of funding (total direct plus indirect for 3 years) is approximately 1.6 million dollars. This project investigates the hypothesis that Rad modulates the interdependent relationship between LTCC and 尾-AR signaling and that Rad deficiency promotes protection against adverse myocardial remodeling.
Jessica Blackburn
St. Baldrick's Foundation for Pediatric Cancer Research:
"Protein Tyrosine Phosphatases as Novel Drugs Targets in Acute Lymphoblastic Leukemia"
$100,000. 6/1/17-5/30/18. This goal of this research is to use zebrafish screens and human leukemia cells to identify FDA-approved
tyrosine phosphatase inhibitors that can be repurposed as targeted anti-cancer therapy in pediatric leukemia.
NCI Supplement:
"Development of Fusion Oncoprotein Models in Zebrafish"
$163,000. 8/1/17-11/30/18. In response to the Cancer Moonshot Initiative, and in collaboration with St. Jude Children's Research Hospital, this project will use CRISPR technology to develop the first zebrafish models of translocations common to pediatric cancers, with the goal of developing new high- throughput, in vivo drug screening tools.
NIH New Innovator Award:
"Harnessing Single-Cell Technology to Define Self-Renewal of Normal and Malignant Stem Cells"
$2.3 million, 9/1/17-8/30/22. This project utilizes zebrafish leukemia models for single-cell sequencing and high resolution in vivo imaging to define the unique biological properties of cancer stem cells, to understand how they respond to chemotherapy in vivo, and to identify new ways to target them therapeutically to prevent leukemia relapse.
Trevor Creamer
COBRE Pilot Award:
鈥淚nterplay Between Calcineurin, Rcan1, and Tau in Alzheimer鈥檚 Disease鈥
$100,000, 5/1/2017-4/30/2018. In this project, we are investigating tau undergoing liquid-liquid phase separation, how that is affected by phosphorylation state and dephosphorylation by calcineurin and the role of Rcan1 in modulating these processes.
VPR Research Support Grant:
鈥淚nhibition of Calcineurin by Rcan1 and Hyperphosphorylation of Tau in Alzheimer鈥檚 Disease鈥
$10,000, 7/1/2017-6/30/2017. The goal of this project is to determine the extent to which Rcan1 inhibits calcineurin鈥檚 dephosphorylation of tau and how that contributes to neurofibrillary tangle formation in Alzheimer鈥檚 disease.
Robert Dickson
R56 Grant:
鈥淐haracterization of the Sch9 Longevity Pathway in Yeast鈥
The amount of funding (direct plus indirect) is $382,500, and the grant runs from 09/01/2017 to 08/31/2018.
Emilia Galperin
NIH S10 Award
Matt Gentry
Industry Sponsored Project: Valerion Therapeutics:
鈥淒efining the Action of Fab-Amylase as a Putative Therapeutic for LD鈥
The amount of funding is $415,000 and the grant runs from 2017-2019.
Konstantin Koroktov
Multi-PI COBRE Pilot Grant:
鈥淪tructural and Biochemical Perspective of Cell-Wall Biosynthesis in Gram-Positive Bacteria鈥
The amount of funding is $50,000 and the grant runs from 2017-2018. The main objective of the grant is to elucidate the mechanism of biogenesis of Group-specific polysaccharides in pathogenic Streptococci.
(With Natalia Korotkov and Jeffrey Rush)
Stefan Stamm
PI on an R21
鈥淐hanging Serotonin Receptor 2C Splice Variants to Combat Spasticity After Spinal Cord鈥
The award is in the amount of $225,750.
Grant for Prader Willi Research
Sidney Whiteheart
RO1 Grant
鈥淢olecular Mechanism of Platelet Exocytosis鈥
The amount of funding is $1,881,250, with a grant period from 2017-2021.
VA Merit Award
鈥淭argeting Platelet Endocytosis and Exocytosis to Control Thrombosis鈥
The amount of funding is $928,269 and the grant runs from 2017- 2021.
RO1
鈥淧latelet Endocytosis to Innate Immunity鈥
The amount of funding is $2,044,892 and the grant runs from 2017-2021.
COBRE Pilot Award
Haining Zhu
Kentucky Lung Cancer Research Program Grant
鈥淎cetylation of G3BP1 in Lung Cancer鈥
The amount of funding is $150,000 for the period 07/01/2017 to 06/30/2019. The major goal of the grant is to determine whether G3BP1 acetylation can promote lung cancer progression and whether targeting G3BP1 acetylation provides a novel therapeutic avenue for lung cancer.