Alzheimer's Disease Research Center
Alzheimer's Disease Research Center
An integral part of Sanders-Brown Center on Aging (SBCoA) is the National Institute on Aging-funded University of Kentucky Alzheimer's Disease Research Center (ºÃÉ«ÏÈÉú-ADRC). Over the past 40 years, the ºÃÉ«ÏÈÉú-ADRC has developed a vigorous program in the clinical, neuropathological, educational, and research aspects of Alzheimer's disease that serves as a critical resource for the university, community, state, and nation.
September 2022 — A team of researchers at the University of Kentucky’s Sanders-Brown Center on Aging (SBCoA) is awarded a $20.5 million grant from the National Institute on Aging (NIA) of the National Institutes of Health (NIH) to continue and further research and clinical initiatives geared toward beating Alzheimer’s disease and other forms of dementia. In 1985, SBCoA was among the first 10 ADCs funded by the NIH and has been continuously funded since the designation was launched.
Overview
The University of Kentucky Alzheimer’s Disease Research Center (ºÃÉ«ÏÈÉú-ADRC) is a NIH-funded (P30 AG072946) mature and experienced ADRC. The ºÃÉ«ÏÈÉú-ADRC is housed in the Sanders-Brown Center on Aging (SBCoA), a Kentucky Center of Excellence that facilitates clinical and basic research in healthy brain aging and neurodegenerative disorders.
Our principal mission is to serve as the focal point for all Alzheimer’s disease-related activities at ºÃÉ«ÏÈÉú and the Commonwealth of Kentucky, by providing an environment and core resources that catalyze innovative research, outreach, education, and clinical programs.
Over the past 40 years, we have developed a vigorous program in the clinical, neuropathological, educational, and research aspects of Alzheimer’s disease that serves as a critical resource for the university, community, state, and nation.
Two of the historically outstanding facets of the ºÃÉ«ÏÈÉú-ADRC are:
Autopsy Program
A strong autopsy program providing clinical-neuropathological correlation and short postmortem interval (PMI) research material.
Data / Subjects
A unique, continuously replenished group of ~500 cognitively intact subjects followed longitudinally, together with the initially normal who transition to MCI or Alzheimer’s disease, and all committed to brain donation upon death.
These signature resources have contributed to our becoming one of the premier center’s defining pathogenic mechanisms underlying the transitions from normal cognitive aging to Alzheimer’s disease.
Goals
The ºÃÉ«ÏÈÉú-ADRC focus is on two interrelated themes: transitions and translation. Our overall emphasis is to more effectively bridge the gap between basic research and clinical studies by facilitating translational efforts. We will also carefully characterize transitions across the spectrum of cognitive impairment (normal/preclinical Alzheimer’s disease/ MCI/ dementia), with focus on definition of early disease.
The ADRC provides an infrastructure and environment that focus on these integrated themes and advance multidisciplinary, innovative Alzheimer’s disease research through the pursuit of six overall aims.
Leadership
Provide strong leadership and an administrative structure that support and facilitate basic and clinical research to understand the early transitions to cognitive decline and identify potential intervention strategies that promote cohesiveness and dynamic interactions among the cores to create new opportunities for innovative Alzheimer’s disease research at ºÃÉ«ÏÈÉú and beyond, and support NIA major initiatives.
Support
Support a clinical core that maintains a central longitudinal cohort of 500 cognitively intact subjects and 300 cognitively impaired subjects with a major focus on early cognitive transitions from normal and from mild cognitive impairment to facilitate research projects, and use this infrastructure to support an integrated translational clinical trials team to evaluate potential new therapeutic interventions.
Maintain
Maintain and expand the successful Minority Gateway Satellite Clinic to recruit African Americans, with overall goals that emphasize clinical evaluation and longitudinal follow-up, education of the community about Alzheimer’s disease, and increased participation in research.
Data Management and Statistical Core
Continue the data management and statistical core (DMSC) that maintains an integrated centralized database, provides expertise on experimental design and analysis, and interfaces with other ADRCs and with NACC. The BDMC will contribute innovative statistical expertise to characterize clinical transitions.
Neuropathology
Maintain a neuropathology core that performs state-of-the-art neuropathological services for the ºÃÉ«ÏÈÉú-ADRC clinical cohort and maintains a tissue bank from well-characterized, short PMI autopsy subjects from across the cognitive spectrum, as well as serum and CSF from living subjects to support research.
Outreach, Recruitment, and Engagement Core
Continue outreach efforts to support recruitment and retention activities, increase community awareness of Alzheimer’s disease, and support engagement initiatives.
2025 Marks the 40th Anniversary of the ºÃÉ«ÏÈÉú Sanders-Brown Center on Aging Alzheimer's Disease Research Center
Forty years ago, the National Institute on Aging launched its ADRC grants program, and Sanders-Brown was among the prestigious first class of just 10 awardees. We continue to carry that designation, world-renowned for our significant contributions to the field of aging. See below for more details!
Center Brochure
The Center brochure highilghts the mission, historical timeline, grants and contracts, and outreach efforts.
Behind the Blue
Center Director, Dr. Linda Van Eldik, discusses the center’s 40-year journey, focusing on its origins, community engagement and the evolution of Alzheimer's research.
History & Accomplishments
The Alzheimer's Disease Research Center celebrates many achievements, including advancing our understanding of dementia and risk factors as well as making an impact in the community. To learn more,