Subbarao Bondada, PhD

Connect

Office: (859) 323-4705
bondada@email.uky.edu
Office: 212 Combs Research Bldg.

Positions

  • Professor

College Unit(s)

Other Affiliation(s)
  • Markey Cancer Center
  • Toxicology - Joint Faculty

Biography and Education

Education

B. Sc. (Mathematics, Physics and Chemistry) Andhra Loyola College, Vijayawada, Andhra Pradesh, India M. Sc. (Chemistry) Indian Institute of Technology (IIT), Kanpur, India Ph.D. Tata Institute of Fundamental Research, Mumbai, India

Research

Doctoral Studies: Tata Institute of Fundamental Research, Bombay. Postdoctoral: National Institute of Health, Bethesda, MD and Institute for Cancer Research, Philadelphia, PA.

Research Statement:

 

  • B-CLL is a leukemia primarily seen in adults. CLL cells are unlike most cancers in that they exhibit very little proliferation but survive for long time in vitro and in vivo. In 2019 21000 new CLL cases are expected to be diagnosed, along with 400 deaths due to CLL. It is an incurable disease with an estimated cost of 5.1 billion dollars in medical care costs. We are determining if the tonic BCR signaling is also important for B-CLL using murine and human models. In CLL we are studying the role of the tumor suppressor gene, Par-4 on CLL growth. In addition, we are also investigating the role of CLL-derived IL-10 in cancer immunotherapy.
  • Chemobrain is a condition experienced by cancer patients treated with chemotherapy, radiation, and immunotherapy. It consists in variable loss of executive function affecting the quality of life for cancer survivors. We are working with a group of researchers at 好色先生MC, to test the hypothesis that circulating extracellular vesicles carrying oxidized proteins stimulate immune cells to produce cytokines that have neurotoxic effects in cancer patients undergoing or completing their therapies.

Selected Publications

Selected Recent Publications:

Collard JP, McKenna MK, Noothi SK, Alhakeem SS, Rivas JR, Rangnekar VM, Muthusamy N, Bondada S.Leuk Lymphoma. 2022 Aug;63(8):1810-1822. doi: 10.1080/10428194.2022.2045596. Epub 2022 Mar 8.PMID: 35258388
Chemotherapy

Rummel NG, Chaiswing L, Bondada S, St Clair DK, Butterfield DA.Cell Mol Life Sci. 2021 Oct;78(19-20):6533-6540. doi: 10.1007/s00018-021-03925-4. Epub 2021 Aug 23.PMID: 34424346 Free PMC article. Review.

Sukati S, Ho J, Chaiswing L, Sompol P, Pandit H, Wei W, Izumi T, Chen Q, Weiss H, Noel T, Bondada S, Allan Butterfield D, St Clair DK.Brain Res. 2022 May 1;1782:147840. doi: 10.1016/j.brainres.2022.147840. Epub 2022 Feb 17.PMID: 35183524 Free PMC article.

Rivas JR, Liu Y, Alhakeem SS, Eckenrode JM, Marti F, Collard JP, Zhang Y, Shaaban KA, Muthusamy N, Hildebrandt GC, Fleischman RA, Chen L, Thorson JS, Leggas M, Bondada S.Leukemia. 2021 Nov;35(11):3188-3200. doi: 10.1038/s41375-021-01217-1. Epub 2021 Mar 17.PMID: 33731852 Free PMC article.

Yarana C, Thompson H, Chaiswing L, Butterfield DA, Weiss H, Bondada S, Alhakeem S, Sukati S, St Clair DK. Redox Biol. 2019 Sep;26:101237. doi: 10.1016/j.redox.2019.101237. Epub 2019 Jun 5. PubMed PMID: 31276937; PubMed Central PMCID: PMC6612011.

Ren X, Boriero D, Chaiswing L, Bondada S, St Clair DK, Butterfield DA. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1088-1097. doi: 10.1016/j.bbadis.2019.02.007. Epub 2019 Feb 10. Review. PubMed PMID: 30759363; PubMed Central PMCID: PMC6502692.

Greene JT, Mani R, Ramaswamy R, Frissora F, Yano M, Zapolnik K, Harrington B, Wasmuth R, Tran M, Mo X, McKenna M, Rangnekar VM, Byrd JC, Bondada S, Muthusamy N. Blood Adv. 2019 Apr 23;3(8):1255-1266. doi: 10.1182/bloodadvances.2018025973. PubMed PMID: 30987970; PubMed Central PMCID: PMC6482354.

Ren X, Keeney JTR, Miriyala S, Noel T, Powell DK, Chaiswing L, Bondada S, St Clair DK, Butterfield DA. Free Radic Biol Med. 2019 Apr;134:1-8. doi: 10.1016/j.freeradbiomed.2018.12.029. Epub 2018 Dec 26. PubMed PMID: 30593843; PubMed Central PMCID: PMC6588453.

Alhakeem SS, McKenna MK, Oben KZ, Noothi SK, Rivas JR, Hildebrandt GC, Fleischman RA, Rangnekar VM, Muthusamy N, Bondada S.

J Immunol. 2018 Jun 15;200(12):4180-4189. doi: 10.4049/jimmunol.1800241. Epub 2018 Apr 30.

PMID:29712773

McKenna MK, Noothi SK, Alhakeem SS, Oben KZ, Greene JT, Mani R, Perry KL, Collard JP, Rivas JR, Hildebrandt GC, Fleischman RA, Durbin EB, Byrd JC, Wang C, Muthusamy N, Rangnekar VM, Bondada S. Blood. 2018 Jun 28;131(26):2943-2954. doi: 10.1182/blood-2017-10-813931. Epub 2018 Apr 25. PubMed PMID: 29695515; PubMed Central PMCID: PMC6024641.

Oben KZ, Alhakeem SS, McKenna MK, Brandon JA, Mani R, Noothi SK, Jinpeng L, Akunuru S, Dhar SK, Singh IP, Liang Y, Wang C, Abdel-Latif A, Stills HF Jr, St Clair DK, Geiger H, Muthusamy N, Tohyama K, Gupta RC, Bondada S. Oncotarget. 2017 Sep 29;8(44):77436-77452. doi: 10.18632/oncotarget.20497. eCollection 2017 Sep 29. PubMed PMID: 29100399; PubMed Central PMCID: PMC5652791.

Liu Y, Zhang C, Li Z, Wang C, Jia J, Gao T, Hildebrandt G, Zhou D, Bondada S, Ji P, St Clair D, Liu J, Zhan C, Geiger H, Wang S, Liang Y.

Stem Cell Reports. 2017 Apr 11;8(4):991-1004. doi: 10.1016/j.stemcr.2017.02.009. Epub 2017 Mar 16.

PMID:28330618

 

Agrawal AK, Aqil F, Jeyabalan J, Spencer WA, Beck J, Gachuki BW, Alhakeem SS, Oben K, Munagala R, Bondada S, Gupta RC.

Nanomedicine. 2017 Jul;13(5):1627-1636. doi: 10.1016/j.nano.2017.03.001. Epub 2017 Mar 11.

PMID:28300659

Zhao Y, Carroll DW, You Y, Chaiswing L, Wen R, Batinic-Haberle I, Bondada S, Liang Y, St Clair DK.

Redox Biol. 2017 Aug;12:129-138. doi: 10.1016/j.redox.2017.02.005. Epub 2017 Feb 10.

PMID:28231483

 

Select item 280811765.

Oben KZ, Gachuki BW, Alhakeem SS, McKenna MK, Liang Y, St Clair DK, Rangnekar VM, Bondada S.

PLoS One. 2017 Jan 12;12(1):e0169767. doi: 10.1371/journal.pone.0169767. eCollection 2017.

PMID:

28081176

Carroll D, Howard D, Zhu H, Paumi CM, Vore M, Bondada S, Liang Y, Wang C, St Clair DK. Free Radic Biol Med. 2016 Aug;97:85-94. doi: 10.1016/j.freeradbiomed.2016.05.005. Epub 2016 May 19. PubMed PMID: 27212018; PubMed Central PMCID: PMC4996720.

 

 Mckenna MK, B. W. Gachuki, S. S. Alhakeem, K. N. Oben, V. M. Rangnekaar, R. C. Gupta, S. Bondada Anti-cancer activity of withaferin A in B-cell lymphoma in Cancer Biol Thera. 2015 May 28:0

Alhakeem SS, Sindhava VJ, McKenna MK, Gachuki BW, Byrd JC, Muthusamy N, Bondada S.

Ann N Y Acad Sci. 2015 Dec;1362:239-249. doi: 10.1111/nyas.12802. Epub 2015 Jun 11.

PMID:26096907

Gururajan, M. *, V. J. Sindhava* and S. Bondada. B cell tolerance in health and disease in Antibodies. 3, 116-129 (2014)

Tuna H, Avdiushko RG, Sindhava VJ, Wedlund L, Kaetzel CS, Kaplan AM, Bondada S, Cohen DA. J Leukoc Biol. 2014 Mar;95(3):471-85. doi: 10.1189/jlb.0713408. Epub 2013 Dec 2. PubMed PMID: 24295831; PubMed Central PMCID: PMC3923081.

Sindhava, V. * and S. Bondada. Multiple regulatory mechanisms control B-1 B cell activation. Frontiers in Immunology 3: 372 (2012)

Fallah MP, Chelvarajan RL, Garvy BA, Bondada S. Mech Ageing Dev. 2011 Jun-Jul;132(6-7):274-86. doi: 10.1016/j.mad.2011.05.003. Epub 2011 May 27. PMID:21645538

Zhao Y, Burikhanov R, Brandon J, Qiu S, Shelton BJ, Spear B, Bondada S, Bryson S, Rangnekar VM. Cancer Biol Ther. 2011 Jul 15;12(2):152-7. Epub 2011 Jul 15. PMID: 21613819

Bieging KT, Fish K, Bondada S, Longnecker R. Blood. 2011 Dec 22;118(26):6849-59. doi: 10.1182/blood-2011-02-338434. Epub 2011 Oct 28. PMID: 22039254

  Frantz AL, Bruno ME, Rogier EW, Tuna H, Cohen DA, Bondada S, Chelvarajan RL, Brandon JA, Jennings CD, Kaetzel CS. Inflamm Bowel Dis. 2012 Nov;18(11):2138-48. doi: 10.1002/ibd.22923. Epub 2012 Feb 22. PMID: 23070952
Sindhava VJ, Tuna H, Gachuki BW, DiLillo DJ, Avdiushko MG, Onami TM, Tedder TF, Cohen DA, Bondada S. J Immunol. 2012 Oct 1;189(7):3355-67. Epub 2012 Aug 31. PMID: 22942427

Liu Y, Howard D, Rector K, Swiderski C, Brandon J, Schook L, Mehta J, Bryson JS, Bondada S, Liang Y. PLoS One. 2012;7(9):e44979. doi: 10.1371/journal.pone.0044979. Epub 2012 Sep 27. PMID: 23028717

Sindhava VJ, Bondada S. Front Immunol. 2012;3:372. doi: 10.3389/fimmu.2012.00372. Epub 2012 Dec 17. PMID: 23251136 [PubMed]

Sultana, R. , F. Di Domenico, M Tseng, J. Cai , T. Noel , R. L. Chelvarajan, W. D. Pierce, C. Cini , S. Bondada , D. K. St Clair, and D. A. Butterfield. Doxorubicin-Induced Thymus Senescence. J Proteome Res. 2010 Dec 3;9(12):6232-6241. Epub 2010 Nov 9.PMID: 20945937.

Brandon, J., J. Jennings CD, Cohen DA, Sindhava VJ, Bondada S, Kaplan AM, Bryson JS.     Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G602-13. Epub 2010 Jul 15.PMID: 20634434

Sindhava, V., M. Woodman, B. Stevenson and S. Bondada Interleukin-10 mediated autoregulation of murine B-1 B-cells and its role in Borrelia hermsii infection. PLOS One 2010 Jul 6;5(7):e11445.PMID: 20625435

Ke, J., Chelvarajan, L., Sindhava, V., Lekakis, L., Jennings, D.J. and S. Bondada (2009) Anomalous constitutive Src kinase activity promotes B lymphoma survival and growth. Molec. Cancer Dec 31;8:132-147. PMID: 20043832.

Dasu, T., V. Sindhava, S. G. Clarke and S. Bondada. CD19 signaling is impaired in murine peritoneal and splenic B-1 B lymphocytes. Molecular Immunology 46: 2655-2665 (2009).

Wu,H.-S. and S. Bondada CD72, a coreceptor with both positive and negative effects on B lymphocyte development and function. J. Clin. Immunol. 29:12-21 (2009) DOI: 10.1007/s10875-008-9264-6

Gururajan, M., A. Simmons, T. Dasu, B. T. Spear, C. Calulot, D. Robertson, D. Wiest, J. Monroe and S. Bondada. Early growth response gene-1 is required for B cell    development, proliferation and immune response. J. Immunol  181(7):4590-602 (2008)

Bondada, S. and M. Gururajan. Importance of B cell receptor signaling for B lymphoma growth. PLOS Biol. (2008) Comment on Refaeli Y, Young RM, Turner BC, Duda J, Field KA, et al. PLoS Biology Vol. 6, No. 6, e152 doi:10.1371/journal.pbio.0060152

Dasu, T., J. E. Qualls, C. Raman, D. A. Cohen and S. Bondada. CD5 plays an inhibitory role in the suppressive function of T-regulatory cells Immunol. Lett. 2008;119(1-2):103-13.

Yanming Zhao, R. Burikhanov, S. Qiu, S. M. Lele, S. Bondada, B. Spear, and V. M.  Rangnekar. Cancer resistance in transgenic mice expressing the SAC module of Par-4. Cancer Res 67:9276-9285 (2007).

Chelvarajan, R. L., D. Popa, Y. Liu, T.V. Getchell, A.J. Stromberg and S. Bondada.  Molecular mechanisms underlying anti-inflammatory phenotype of neonatal macrophages. J. Leuk. Bol. 82:403-16. (2007)

Gururajan, M., T. Dasu, S. Shahidain, C. D. Jennings, D. A. Robertson, V. M.  Rangnekar and S. Bondada.   Curcumin inhibits B lymphoma growth by suppressing Syk, a novel target. J. Immunol. 178: 111-121(2007).

Ke, J., M. Gururajan, A. Kumar, A. Simmons, L. Turcios, Ralph L. Chelvarajan, D. M. Cohen, D. Wiest, J.  Monroe and S. Bondada. The role of MAP Kinases in BCR induced down鈥憆egulation of Egr-1 in immature B lymphoma cells. J. Biol. Chem. 281(52):39806-18 (2006).

Landers, C.D. and Subbarao Bondada What insights into human cord blood lymphocyte function can be gleaned from studying newborn mice Questions and Controversies in Neonatology Series, Hematology, Immunology, and Infectious Diseases Volume; Editors: Robin Ohls, and Mervin C. Yoder,  (2006).

Gururajan, M., C. D. Jennings, and S. Bondada. Cutting Edge: ConstitutiveB cell receptor signaling is critical for basal growth of B lymphoma. J. Immunol. 176: 5715-5719 (2006).

S. Bondada and H-S. Wu Molecule Page, A000582, CD72, AfCS-Nature Molecule Pages (2006) (peer reviewed like any journal manuscript).

Chelvarajan, R. L., Y. Liu, D. Popa, M.L. Getchell, T.V. Getchell, A.J. Stromberg and S. Bondada.  Molecular basis of age associated cytokine dysregulation in macrophages. J. Leuk. Bol. 79: 1314-1327 (2006).

Bikah, G. *, J. Carey*, J. Ciallella, A. Tarakhovsky and S. Bondada. CD5 Mediated Negative Regulation of Antigen Receptor-Induced Growth Signals in B-1 B cells. Science 274 (5294): 1906-1909 (1996). PMID: 8943203