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William O'Connor, MD

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woconno@uky.edu
MS 137

Positions

  • Professor
  • Associate Director, Autopsy
  • Director of Surgical Pathology Fellowship Program

College Unit(s)

Biography and Education

Education

MD - National University of Ireland (1972)
AP Residency - Georgetown University (1975)

Selected Publications

Publications & Other Scholarly Work:

1     Dana Ionel DO, Fred Odago MD, A. E. Ene, MD, William N. O鈥機onnor MD, Jessica D. Lee MD, Luther C. Pettigrew MD: Cerebral Air Embolism Complicating Atrio-esophageal Fistula in Williams Syndrome. Annals of Clinical and Translational Neurology

2     Roberto G. Aru, Jerald P. Wallace, Michael C. Bounds, Mary B. Sheppard, Akif K. Guney, William N. O'Connor, Sam C. Tyagi Spontaneous Rupture of Mesenteric Vasculature Associated with Fibromuscular Dysplasia in a 28-Year-Old Male Annals of Vascular Surgery, 2021-02-01, Volume 71, Pages 534.e13-534.e15,

3     Snigdha Nutalapati, Richard O'Neal, William O'Connor, Brett T. Comer, Gerhard C. Hildebrandt. Challenges in Medicine: The Odyssey of a Patient with Isolated IgG4-Related Eosinophilic Angiocentric Fibrosis Presenting as a Locally Destructive Sinonasal Mass Case Rep Rheumatol. 2021; 2021: 6668184. Published online 2021 Mar9. doi: 10.1155/2021/6668184

4     Zwischenberger, Brittany A.鈥燘alasuriya, Beverly K.鈥燞arris, Dwight D.鈥燦ataraj, Nisha鈥燨wen, Allison M.鈥runo, Maria E. C.鈥燤ukherjee, Sujata搂Ortiz-Soriano, Victor|| O鈥機onnor, William露Ke, Chenlu#Stromberg, Arnold J.#Chang, Phillip K.鈥燦eyra, Javier A.||Saito, Hiroshi鈥tarr, Marlene E.搂 Adipose-Derived Inflammatory and Coagulant Mediators in Patients With Sepsis Shock. May 2021, Volume 55 (5), p 596鈥�606.

5     Rajagopalan N, Dennis D, and O鈥機onnor W. Successful combined heart and kidney transplantation in patient with Fabry鈥檚 disease. A case report. Transplantation Proceedings XX, 1e3 (2019).

6     Tretter JT, Tran VH, Gray S, Ta H, Loomba RS, O鈥機onnor W, Spicer DE, Cook AC, Anderson RH: Assessing the Criteria for Definition of Perimembranous Ventricular Septal Defects in Light of the Search for Consensus. Orphanet Journal of Rare Diseases 2019; April 3;14

7     Purushothaman K, Purushothaman M, Turnbull I, Adams D, Anyanwu A, Krishnan P, Kini A, Sharma S, O鈥機onnor W, Moreno P: Association of altered collagen content and lysyl oxidase expression in degenerative mitral valve disease. Cardiovascular Pathology 29 :11-18, 2017.

8     Sudhakar P, Tobin S, O鈥機onnor W, Kedar S: Neuro-Ophthalmic Presentation of Neuro-Sweet Disease. Neuro-Ophthalmology, DOI: 10.1080/01658107. 2017.1291687

9     Stewart RL, West D, Wang C, Weiss HL, Gal T, Durbin EB, O鈥機onnor W, Chen M, O鈥機onnor KL:  Elevated integrin 伪6尾4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancer Human Pathology 54 174-183. 2016.

10   Bennett G, Hager m, Cornea V, O鈥機onnor W, Guglin M: Fulminant Necrotizing Eosinophilic Myocarditis: A case report and comprehensive review of the literature. The VAD Journal:. 2016.

11   Purushothaman K, Krishnan P, Purushothaman M, Baber U, Tarricone A, Vasquez M, Wiley J, Kini A, Sharma S, O鈥機onnor W, Moreno P: Increased Internal Elastic Lamellar Layer Disruption to Neointimal Cellular Proliferation and Type III Collagen Deposition in Human Peripheral Artery Restenosis. Am J Cardiol 2016; 117: 1173 - 1179.

12   Seratnahaei A, Bailey A, Hensley P, O鈥機onnor W, Smith M: Infective endocarditis complicated by mitral valve aneurysm: pathologic and echocardiographic correlations. Echocardiography 2015; 32: 1417-1422.

13   VanDerPloeg D, Strong WR, Krohmer S, O鈥機onnor W, Martin J: Congenital bronchial artery to pulmonary artery fistula presenting as hemoptysis. Ann Thorac Surg 2015; 99:e19-20

14   Rateri D, Davis FR, Balakrishnan A, Howatt D, Moorleghen JJ, OConnor WN, Charnigo R, Cassis LA, Daugherty A: Angiotensin II induces region-specific medial disruption during evolution of Ascending Aortic Aneurysms. Am J Pathol 184 (9) 2586-2595, 2014.

15   Chau, D. F., Srour, H., Rolf, C. M., O'Connor, W. N., Cumbermack, K. M., Bezold, L. I., Kozik, D. J., Plunkett, M., Murphy, J. T., Hessel, E. A. (2013). Death by late-presenting Bochdalek hernia in infant soon after congenital cardiac repair.  World Journal of Pediatric Congenital Heart Surgery, 4(2), 213-6, 2013

16   Martin JT, O鈥機onnor WN, Ramaiah C: Isolated necrotizing aortitis presenting Incidental Thoracoabdominal Aortic Aneurysm 鈥� a case report.  Int J Angiology 20(1) 59-62, 2011

17   Purushothaman KR, Purushothaman M, Muntner P, Lento PA, O鈥機onnor WN, Sharma SK, Fuster V, Moreno PR. Inflammation, neovascularization and intraplaque hemorrhage are associated with increased collagen content: implications for plaque progression in diabetic atherosclerosis. Vascular Medicine 2011; 16:103-108.

18   Lin AE, Alexander ME, Colan SD, Kerr B, Rauen KA, Noonan JA, Baffa J, Hopkins E, Sol-Church K, Limongelli G, Diglio MC, Marino B, Innes AM, Aoki Y, Silberbach M, Delrue MA, White SM, Hamilton RM, O鈥機onnor W, et al: Clinical, Pathological and Molecular Analyses of Cardiovascular Abnormalities in Costello Syndrome 鈥� A Ras/MAPK Pathway Syndrome. Am J Med Genetics 2011; 155:486-507.

19   Ramos JM, Davis GD, O鈥機ONNOR WN.  Cor Pulmonale Secondary to Multiple Pulmonary Thromboemboli in a Patient with Klippel-Trenaunay Syndrome.  Am J of Forensic Med Pathol

20   Ohebsion J, O鈥機ONNOR WN, Attili AK, Diaz-Guzman E.  A Thirty Year Old Man with Facial Flushing and a Mediastinal Mass.  Chest 2010;138:746-49.

21   Echeverri D, Purushothaman KR, Kilpatrick D, O鈥機ONNOR WN, Moreno PR: Plaque stabilization by bare metal and drug-eluting stents in an experimental model of thin cap fibroatheroma. (Portuguese) Rev Bras Cardiol Invas. 2008; 16(2); 170-177.

22   Moreno PR, Purushothaman, KR, Fuster V, Echeverri D, Truszczynska H, Sharma SK, Badimon JJ, O鈥機ONNOR WN:  Neovascularization is increased in ruptured atherosclerotic lesions of human aorta: Implications for plaque vulnerability.  Circulation 2004; 110: 2032-38.

23   Moreno PR, Purushothaman, KR, Fuster V, O鈥機ONNOR WN:  Intimomedial Interface Damage and Adventitial Inflammation is Increased Beneath Disrupted Atherosclerosis in the Aorta: Implications for Plaque Vulnerability. Circulation 105:2504-2511, 2002.

24   Moreno PR; Lodder RA, Purushothaman KR, Charash WE, O鈥機ONNOR WN, Muller JE:  Detection of Lipid Pool, Thin Fibrous Cap, and Inflammatory Cells in Human Aortic Atherosclerotic Plaques by Near-Infrared Spectroscopy. Circulation 105:923-927, 2002.

25   Dishop MK, O鈥機ONNOR WN, Abraham S, Cottrill CM:  Primary Cardiac Lipoblastoma. Pediatr Dev Pathol 4(3):276-280, 2001.

26   Leonelli F, Pisano E, Requarth J, Potenza D, Tomassoni G, O鈥機ONNOR W, Natale A:  Frequency of superior vena cava syndrome following radiofrequency modification of the sinus node and its management. Am J Cardiol 85:771-774, 2000.

27   Cottrill HM, O鈥機ONNOR WN:  The Autopsy in the 21st Century:  Time for Reconsideration. J Kentucky Med A 98:110-114, 2000.

28   Leonelli FM, Natale A, O鈥機ONNOR W:  Human histopathologic findings following radiofrequency ablation of the Tricuspid-Inferior vena cava isthmus. J Cardiovasc Electophysiol 10:599-602, 1999.

29   Cottrill CM, Ho SY, O鈥機ONNOR W:  Embryological development of equine heart. World Equine Vet Review.  Vol 3(1):28-33, 1998.

30   Skinker DM, Cottrill CC, O鈥機ONNOR W.  Right ventricular biopsy findings of hypertrophic cardiomyopathy in a patient with Noonan syndrome. Cardiology in the Young.  8:256-259, 1998.

31   Cottrill CM, Ho SY, O鈥機ONNOR W:  Embryological development of equine heart. Equine Vet J Suppl 24:14-18, 1997.

32   Chien S, Maley R, Oeltgen P, O鈥機ONNOR W, Wu G, Zhang F, Salley R:  Canine lung transplantation after more than 24 hours of normothermic preservation. J Heart Lung Transplant 16:340-51, 1997

33   Noonan J, O鈥機ONNOR W: (By invitation 6/95) Noonan syndrome: A clinical description emphasizing the cardiac findings. Acta Pediatrica Japonica 38:76-83, 1996

34   Schneider D, Cottrill C, O鈥機ONNOR W, Salley R:  Right ventricular outflow muscle in Tetralogy of Fallot: Histologic and immunohistochemical monoclonal antibody analysis. Cardiovascular Pathology 5:121-131, 1996.

35   Cottrill CM, O鈥機ONNOR W:  A cardiac tale of flies, fish, birds and beasts. Proceedings of the International Society of Veterinary Perinatology, Cambridge United Kingdom, July 1995.

36   Winters J, O鈥機ONNOR W, Geil J:  Immunohistology, Cytogenetics and Molecular studies of small round cell tumors of childhood. Annals of Clinical and Laboratory Science 25:66-78, 1995.

37   Zhang Z, Proffitt G, Salley RK, Diana JN, Zhang F, Wu G, O鈥機ONNOR WN, Chien S:  Autoperfused heart-lung preparation:  one reason for unsuccessful lung preservation. Acta Biomed Ateneo Parmense 65(3-4):115-131, 1994.

38   Chien S, Zhang F, Zhang Z, Wu G, Proffitt G, O鈥機ONNOR WN, Salley RK:  Two-day preservation of the lungs by normothermic perfusion. Acta Biomed Ateneo Parmense 65(3-4):165-169, 1994.

39   Murphy GF, Miller SD, Kenady DE, O鈥機ONNOR WN, Wood DP, McRoberts WF, Gee WF:  Familial paraganglioma. Urology 44(4):273-277, 1994.

40   Hunsaker JC, O鈥機ONNOR WN, Lie JT:  Is spontaneous dissection of the coronary artery with eosinophilia a limited from of Churg-Strauss syndrome? Arch Pathol Lab Med 118(9):863-864, 1994.

41   Bummer PM, Baughn JA, Sanders LP, Tarrence KR, O鈥機ONNOR W, Olson JW, and Gillespie MN:  Surfactant disposition in monocrotaline-induced pneumotoxicity. Toxicol 90:53-62, 1994.

42   Gillespie MN, Hartsfield CL, O鈥機ONNOR W, Cohen DA:  Pulmonary hypertension in a murine model of the acquired immunodeficiency syndrome. Am J. Respir Crit Care Med 150:194-199, 1994.

43   Farrell T, Cottrill C, O鈥機ONNOR W, Boucher L, Noonan J:  Dissecting aneurysm of the pulmonary artery - an unusual complication of congenital heart disease. Cardiology in the Young 4:131-135, 1994.

44   Hunsaker J, O鈥機ONNOR W, Lie J:  Spontaneous coronary arterial dissection and isolated eosinophilic coronary arteritis: sudden cardiac death in a limited form of Churg-Strauss syndrome. Mayo Clinic Proceedings 67:761-766, 1992.

45   Cottrill C, O鈥機ONNOR W, Fitz R, Gillespie M:  Pulmonary vascular remodeling in rats with unilaterally banded lobar pulmonary veins. Cardiology in the Young 2:121-128, 1992.

46   Winters J, O鈥機ONNOR W, Broughton R, Noonan J:  Bordetella bronchiseptica pneumonia in a patient with Down Syndrome: a case report and review. Pediatrics 89(6):7-10, 1992.

47   O鈥機ONNOR W, Cottrill C, Marion M, Noonan J:  Defective regional myocardial development and vascularization in one variant of tricuspid atresia: clinical and necropsy findings in three cases. Cardiology in the Young 2:42-52, 1992.

48   Damm D, O鈥機ONNOR W, White D, Drummond J, Morrow L, Kenady D:  Intraoral sebaceous carcinoma. Oral Surgery, Oral Medicine, and Oral Pathology 72:709-711, 1991.

49   Barton J, Hiett A, O鈥機ONNOR W, Nissen S, Greene J:  Endomyocardial ultrastructural findings in preeclampsia. American Journal of Obstetrics and Gynecology, 165:389-391, 1991.

50   Endean E, Kispert J, Martin K, and O鈥機ONNOR W:  Intimal hyperplasia is reduced by ornithine decarboxylase inhibition. Journal of Surgical Research, 50:634-637, 1991.

51   Shih W, Cottrill C, Coupal T, O鈥機ONNOR W, Kung H, Ryo U:  Iodine-123-HIPDM lung imaging in pulmonary vein-banded pulmonary hypertension. Journal of Nuclear Medicine 31:668-673, 1990.

52   Grines C, Booth D, Nissen S, Gurley J, Bennett K, O鈥機ONNOR W, DeMaria A:  Mechanisms of acute myocardial infarction in patients with prior coronary artery bypass grafting and therapeutic implications. American Journal of Cardiology 65:1292-1296, 1990.

53   Toursarkissian B, O鈥機ONNOR W, Dillon M:  Mediastinal epithelioid hemangioendothelioma. Annals of Thoracic Surgery 49:680-685, 1990.

54   Chien S, Diana J, Oeltgen P, Todd E, O鈥機ONNOR W, Chitwood R:  Eighteen to thirty-seven hours鈥� preservation of major organs using a new autoperfusion multiorgan preparation. Ann Thorac Surg 47:860-867, 1989.

55   Shih W, Flueck J, O鈥機ONNOR W, Domstad P:  Extensive extraosseous localization of bone imaging agent in a patient with renal failure and rhabdomyolysis accompanied by combined hypercalcemia and hyperphosphatemia. Clinical Nuclear Medicine 14:163-167, 1989.

56   Chien S, Diana J, Todd E, O鈥機ONNOR W, Marion T, Smith K:  New autoperfusion preparation for long term organ preservation. Circulation 78(Supp III):58-65, 1988.

57   Wisenbaugh T, O鈥機ONNOR W:  Right ventricular hypertrophy long after reversal of severe pressure overload in the cat. American Journal of Physiology (Heart & Circulatory Physiology 23) 254:H1099-H1104, 1988.

58   O鈥機ONNOR W, Stahr G, Cottrill C, Todd E, Noonan J:  Ventriculocoronary connections in hypoplastic right heart syndrome - autopsy serial section study of six cases. Journal of the American College of Cardiology 11:1061-1972, 1988.

59   Chien S, Todd E, Diana J, and O鈥機ONNOR W:  A simple technique for multiorgan preservation. The Journal of Thoracic and Cardiovascular Surgery 95:55-61, 1988.

60   Kasarskis E, O鈥機ONNOR W, Earle G:  Embolic stroke from cardiac papillary fibroelastomas. Stroke 19:1171-1173, 1988.

61   Gillespie M, Moore C, Wright C, O鈥機ONNOR W:  Salutary effects of prostaglandin E in perfused rat lungs injured with hydrogen peroxide. The Journal of Pharmacology and Experimental Therapeutics 241(1):1-5, 1987.

62   Cottrill C, Cudd T, O鈥機ONNOR W, Rantanen N:  Persistence of fetal circulatory pathways in a newborn foal. Equine Veterinary Journal 19(3):252-255, 1987.

63   Johnson G, O鈥機ONNOR W, Verble S, Cottrill C, Noonan J:  Ventricular septal defect with mobile tricuspid valve pouch mimicking Tetralogy of Fallot. Pediatric Cardiology 7:53-56, 1986.

64   Harrison M, Smith M, O鈥機ONNOR W, DeMaria A:  Post-operative valve ring aneurysm formation, coronary arteritis and myocardial infarction in systemic lupus erythematosus. American Heart Journal 112:414-417, 1986.

65   Gillespie M, Olson J, Reinsel C, O鈥機ONNOR W, Altiere R:  Vascular hyperresponsiveness in perfused lungs from monocrotaline-treated rats. American Journal of Physiology (Heart & Circulatory Physiology 20) 251:H109-H114, 1986.

66   Gillespie M, Owasoyo J, Kiritsy-Roy J, O鈥機ONNOR W, VanLoon G:  Exaggerated nicotine-induced norepinephrine release from atherosclerotic rabbit hearts. Toxicology 37:147-157, 1985.

67   Gillespie M, Dyer K, Olson J, O鈥機ONNOR W, Altiere R:  Alpha-Difluoromethylornithine, an inhibitor of polyamine synthesis, attenuates monocrotaline-induced pulmonary vascular hyperresponsiveness in isolated perfused rat lungs. Research Communications in Chemical Pathology and Pharmacology 50:365-378, 1985.

68   Cottrill C, Davis D, McMillen M, O鈥機ONNOR W, Noonan J, Todd E:  Anomalous left coronary artery from the pulmonary artery.  Significance of associated intracardiac defects. J Amer Coll Cardiol 6:237-242, 1985.

69   O鈥機ONNOR W, Davis J, Geissler R, Cottrill C, Noonan J, Todd E:  Supravalvular aortic stenosis:  Clinical and pathologic observations in six patients. Arch Pathol Lab Med 109:179-185, 1985.

70   Litsey S, Noonan J, O鈥機ONNOR W, Cottrill C, Mitchell B:  Maternal connective tissue disease and congenital heart block: demonstration of immunoglobulin in cardiac tissue. New England Journal of Medicine 312:98-100, 1985.

71   Simon M, Mitchell B, O鈥機ONNOR W, Noonan J, Davis C, Wyatt R:  Glomerulonephritis, pulmonary hemorrhage and coagulopathy associated with Hemophilus para-influenzae endocarditis. Pediatric Infectious Disease 4:183-188, 1985.

72   Wisenbaugh T, Allen P, Cooper G, O鈥機ONNOR W, Mezaros L, Streter F, Bahinski A,    Houser S, Spann J:  Hypertrophy without contractile dysfunction after reversal of pressure overload in the cat. Am Jour Physiol (Heart & Circulatory Physiology) 247:H146-H154, 1984.

73   Christy C, Noonan J, and O鈥機ONNOR W:  Discrete sub-aortic stenosis following Tetralogy of Fallot repair. British Heart Journal 49:510-512, 1983.

74   O鈥機ONNOR W, Hamann S, Hanley H:  Reconstruction of the microscopic transmural edge of experimentally infarcted canine myocardium. British Journal of Experimental Pathology 64:81-86, 1983.

75   Toedebusch W, Hagihara P, van Nagell J, and O鈥機ONNOR W:  Adenocarcinoma of the colon associated with benign appendiceal neoplasm. Southern Medical Journal 75:893, 1982.

76   Mattingly W, O鈥機ONNOR W, Zeok J, Todd E:  Thrombotic catastrophe in the patient with multiple Bjork-Shiley prostheses. The Annals of Thoracic Surgery 33:253-256, 1983.

77   Sampath R, O鈥機ONNOR W, Noonan J, Todd E:  Management of ascending aortic aneurysm complicating coarctation of the aorta. The Annals of Thoracic Surgery 34:125-131, 1982.

78   O鈥機ONNOR W, Valle S:  A combination Verhoeff鈥檚 elastic and Masson鈥檚 trichrome stain for routine histology. Stain Technology 57:207-210, 1982.

79   O鈥機ONNOR W, Cash J, Cottrill C, Johnson G, and Noonan J:  Ventriculocoronary connections in hypoplastic left hearts:  An autopsy microscopic study. Circulation 66:1078-1086, 1982.

80   Mattingly W, O鈥機ONNOR W, Zeok J, Todd E:  General surgical manifestations of Bjork-Shiley prosthetic dysfunction. The American Surgeon 48:207-210, 1982.

81   Powell D, Bivins B, Bell R, O鈥機ONNOR W, Sachatello C, Griffen W:  Endocarditis:  Increasingly a surgical disease. The American Surgeon 48:5-10, 1982.

82   O鈥機ONNOR W, Cottrill C, Johnson G, Noonan J, Todd E:  Pulmonary atresia with intact ventricular septum and ventriculocoronary communications:  Surgical significance. Circulation 65:805-809, 1982.

83   Cornish A, Hanley H, O鈥機ONNOR W, Slack J, Patrick T, and Cole J:  Limitations of post-extrasystolic potentiation in identifying ischemic though viable myocardium. American Journal of Physiology (Heart & Circulatory Physiology) 241:H654-H661, 1981.

84   Noonan J, Kikoshis S, Cottrill C, O鈥機ONNOR W, Haugh R, and Johnson G:  Congenital Heart Disease, butterfly vertebrae, and extrahepatic biliary atresia:  a variant of arteriohepatic dysplasia? The Journal of Pediatrics 99:(3)436-439, 1981.

85   Slack J, Landon J, Cole J, Hanley H, and O鈥機ONNOR W:  Limitations of post-extrasystolic potentiation in assessing regional myocardial viability in man. Catheterization and Cardiovascular Diagnosis 6:373-386, 1980.

86   McComb R, Stahmann F, O鈥機ONNOR W, and Todd E:  Structure-related thrombosis involving a porcine xenograft valve. The Annals of Thoracic Surgery 27(2):191-194, 1979.

87   McComb R, Markesbery W, and O鈥機ONNOR W:  Fetal neonatal nemaline myopathy with multiple congenital anomalies. The Journal of Pediatrics 94(1):47-51, 1979.

88   O鈥機ONNOR W, Challa V, Nelson O, and Gottlieb S:  Extracranial metastases of glioblastoma multiforme:  Report of a case confirmed by electron microscopy. Surgical Neurology 8(5):347-381, 1977.

Book & Book Chapters:

1     Applied Laboratory Medicine.  Tietz N, (Editor) with Conn R, Pruden E.  W. B. Saunders Co., Philadelphia, Pennsylvania (1992)

2     Cardiac & Cardiovascular Diseases:

Case 1.  Child with Heart Murmur and Cyanosis.  O鈥機ONNOR W, and Cottrill C.  p. 7-10.

Case 2.  Woman with Angina Pectoris.  O鈥機ONNOR W, Smith M, Porter W.  p. 11-14.

3     Ischemic Heart Disease.  Falk E, Shah PK, deFeyter, PJ. (Editors). Myocardial        Ischemia: Morbid Demand. 6.1 Cardiac Hypertrophy. pp 74.  Purushothaman KR, O鈥機ONNOR W, Echeverri D, and Moreno PR.   Blackwell Publishing, Inc., United Kingdom, March, 2007.